BiOmimetic fluorinated nanoProbes for multIscale Tumor detection by MRI and Advanced Raman techniques

PNRR M4C2: PRIN 2022

Acronym: OPTIMA


OPTIMA project aims at developing biomimetic Fluorinated NanoParticles (FNP) as bimodal imaging probes for multiscale detection of solid tumors. Such FNP are based on a fluorine-dense core that can be detected by 19F-Magnetic Resonance Imaging (19F-MRI) and Raman spectroscopy.

Main objectives of the project will be on one side, the production of bimodal FNP with enhanced sensitivity for tumor detection by: (1) Synthesizing novel branched fluorinated molecules with a higher number of 19F atoms, increasing both MRI and Raman signal intensity, (2) applying biomimetic strategies to obtain cell membrane coated FNP with prolonged in vivo circulation lifetime and enhanced tumor homing capability. On the other side, (3) optimization of deep Raman technologies enabling the detection of FNP in tissue will be pursued.

Project information

  • Funded by: European Union NextGenerationEU and Italian Ministry of University and Research
  • Call: PNRR: Missione 4 – Componente 2 “Dalla ricerca all’impresa” – Investimento 1.1 – Progetti di Ricerca di Rilevante Interesse Nazionale (PRIN)
  • Start date: 1 October 2023
  • End date: 30 September 2025
  • ISPC Scientific coordinator: Claudia Conti
  • Project Leader: Politecnico di Milano
  • Partners: CNR IFN; Università degli Studi del Piemonte Orientale “Amedeo Avogadro”.
  • Funding: € 198.956

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For further information on the research topic, visit our Groups & Labs

Raman Spectroscopy Lab