{"id":18561,"date":"2024-01-23T12:17:29","date_gmt":"2024-01-23T11:17:29","guid":{"rendered":"https:\/\/www.ispc.cnr.it\/?p=18561"},"modified":"2026-02-04T12:08:23","modified_gmt":"2026-02-04T11:08:23","slug":"optima","status":"publish","type":"post","link":"https:\/\/www.ispc.cnr.it\/it_it\/2024\/01\/23\/optima\/","title":{"rendered":"OPTIMA"},"content":{"rendered":"
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BiOmimetic fluorinated nanoProbes for multIscale Tumor detection by MRI and Advanced Raman techniques<\/h1>\n

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Finanziamenti 2021-2027<\/a><\/span><\/div>

PNRR M4C2: PRIN 2022<\/p>\n<\/div>

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Acronimo: <\/strong>OPTIMA<\/p>\n

Descrizione<\/strong><\/h3>\n

OPTIMA project aims at developing biomimetic Fluorinated NanoParticles (FNP) as bimodal imaging probes for multiscale detection of solid tumors. Such FNP are based on a fluorine-dense core that can be detected by 19F-Magnetic Resonance Imaging (19F-MRI) and Raman spectroscopy.<\/p>\n

Main objectives of the project will be on one side, the production of bimodal FNP with enhanced sensitivity for tumor detection by: (1) Synthesizing novel branched fluorinated molecules with a higher number of 19F atoms, increasing both MRI and Raman signal intensity, (2) applying biomimetic strategies to obtain cell membrane coated FNP with prolonged in vivo circulation lifetime and enhanced tumor homing capability. On the other side, (3) optimization of deep Raman technologies enabling the detection of FNP in tissue will be pursued.<\/p>\n<\/div>

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Informazioni<\/h2>\n